play the song in practice on both and see whcih sounds better to you. if you get to soundcheck, get a bandmate to stand at the back of the venue and try both - too much distortion can be a bad thing, just go with what you like though. I'm slowly learning this through experience - don't try and copy tones, create your own.. (I'm on a Vox Valvetronix, loads of tone variations on that - am trying to perfect a nice clean tone at the moment, the problem beaing my Ibanez is a bit hot pickups wise and won't play nice and mellow... it just wants aggro all the time!)
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Team Japan Owner - GPGNC