Yess! I solved it too!
No, this weird PO problem is not depending on virus scan, fragmentation or other programs, the very high resolution cars are causing this issue.
I had re-build my cars wad, and I don't use the new hi res 2013 cars. If you use new 2013 cars (they have 90 megs textures) and very high res Helmets, you will get this problem.
My new cars.wad is 420 MB, and I don't update the cockpit, it stayed on 2001 version. It's not interesting, most GP4 players are playing in T-Cam mode. I don't have 2013 Williams Fw35 yet, but i think, it will not increase my cars.wad to 900 MB
Use 2007 generic steering wheels, use this rims: Enzojz's 2D Rims Advanced tyre shape (narrower front with camber), 1,3 MB sized helmets.
When I re-build my cars.wad, the game runs smooth and fast (1280x1024) 60 FPS.